Response of Arterial Mechanical Impedance to Different Concentrations of Remifentanil during Abdominal Laparoscopic Colectomy

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タイトル ( eng )
Response of Arterial Mechanical Impedance to Different Concentrations of Remifentanil during Abdominal Laparoscopic Colectomy
作成者
Sukhdorj Elbegzaya
Nakamura Ryuji
Yanabe Kensuke
Hirano Hiroki
Hirano Harutoyo
収録物名
Hiroshima Journal of Medical Sciences
67
3
開始ページ 55
終了ページ 61
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
A specific and reliable method for monitoring analgesia during general anesthesia is urgently required. Previously, we introduced a method that indicates arterial mechanical properties for estimating arterial wall stiffness (K). However, whether the response of K actually indicates changes in remifentanil target concentrations under continuous surgical stress, is unclear. Thus, we aimed to evaluate how K responds to different remifentanil target concentrations.
This prospective study enrolled 30 patients who underwent laparoscopic colectomy. The patients received 3 different effect-site concentrations (2, 4, and 6 ng/ml) of remifentanil 3 times during the study period. The K values at 4-ng/ml administration were used as control values (Kcontrol). K values at 6-ng/ml administration (K6ng) and those at 2-ng/ml administration (K2ng) were normalized by dividing them by the control values. The results showed that K responded to the changes in remifentanil concentration, significantly decreasing at 6-ng/ml remifentanil effect-site concentration and increasing at 2-ng/ml concentration. The stress response at low analgesia was higher than that at high analgesia, and, as predicted, normalized K2ng was significantly greater than normalized K6ng. In conclusion, we found that K is a sensitive stress response monitor and dynamically responds to changes in remifentanil concentration in invasive stimulation during laparoscopic colectomy.
著者キーワード
Photoplethysmogram
Anesthesia
Nociceptive reflex
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 2018-09
権利情報
Copyright (c) 2018 Hiroshima University Medical Press
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
[DOI] 10.24811/hjms.67.3_55
[DOI] https://doi.org/10.24811/hjms.67.3_55