A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome
Hiroshima Journal of Medical Sciences 38 巻 4 号
173-181 頁
1989-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome
|
| 作成者 |
Kato Tadahiro
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 38 |
| 号 | 4 |
| 開始ページ | 173 |
| 終了ページ | 181 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Stereotaxic microinjection of veratrine (50 μg in 1 μl of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 °C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the regions of the thalamus and hypothalamus. Hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). These findings suggest that hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion.
|
| 著者キーワード |
Dopamine
Serotonin
Veratrine
Neuroleptic malignant syndmme
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1989-12 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2637245
|
