A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome
Hiroshima Journal of Medical Sciences Volume 38 Issue 4
Page 173-181
published_at 1989-12
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| File | |
| Title ( eng ) |
A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome
|
| Creator |
Kato Tadahiro
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 38 |
| Issue | 4 |
| Start Page | 173 |
| End Page | 181 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Stereotaxic microinjection of veratrine (50 μg in 1 μl of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 °C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the regions of the thalamus and hypothalamus. Hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). These findings suggest that hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion.
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| Keywords |
Dopamine
Serotonin
Veratrine
Neuroleptic malignant syndmme
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1989-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2637245
|
