Tumorigenicity Study of Sodium Erythorbate Administered Orally to Mice
Hiroshima Journal of Medical Sciences 38 巻 3 号
135-139 頁
1989-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Tumorigenicity Study of Sodium Erythorbate Administered Orally to Mice
|
| 作成者 |
Inai Kouki
Akamizu Hiroshi
Eto Ryozo
Nishida Toshihiro
Ohe Kazuhiko
Kobuke Toshihiro
Nambu Shigeru
Matsuki Kei
Tokuoka Shoji
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 38 |
| 号 | 3 |
| 開始ページ | 135 |
| 終了ページ | 139 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Sodium erythorbate (SE) was administered at concentrations of 0, 1.25, or 2.5% (maximum tolerated dose, MTD) in the drinking-water to groups of 50 male B6C3F1 mice respectively. Female groups, each consisting of 50 mice, received SE in the drinking-water at concentrations of 0, 2.5 or 5% (MTD). Treatment continued for 96 wks and the experiment was terminated during wk 110. Tumors were observed at various sites including the liver, hematopoietic system, lung and soft tissue. However, at any of the sites, the tumor incidence, the time to death with tumors or the histological distribution of tumors did not differ significantly from those in the untreated control group. Thus, the present study did not demonstrate a tumorigenic effect of SE on B6C3F1 mice by means of oral administration.
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| 著者キーワード |
Tumorigenicity
Sodium elythorbate
Mouse
|
| 内容記述 |
This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.
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| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1989-09 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584058
|
