Tumorigenicity Study of Sodium Erythorbate Administered Orally to Mice
Hiroshima Journal of Medical Sciences Volume 38 Issue 3
Page 135-139
published_at 1989-09
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| File | |
| Title ( eng ) |
Tumorigenicity Study of Sodium Erythorbate Administered Orally to Mice
|
| Creator |
Inai Kouki
Akamizu Hiroshi
Eto Ryozo
Nishida Toshihiro
Ohe Kazuhiko
Kobuke Toshihiro
Nambu Shigeru
Matsuki Kei
Tokuoka Shoji
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 38 |
| Issue | 3 |
| Start Page | 135 |
| End Page | 139 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Sodium erythorbate (SE) was administered at concentrations of 0, 1.25, or 2.5% (maximum tolerated dose, MTD) in the drinking-water to groups of 50 male B6C3F1 mice respectively. Female groups, each consisting of 50 mice, received SE in the drinking-water at concentrations of 0, 2.5 or 5% (MTD). Treatment continued for 96 wks and the experiment was terminated during wk 110. Tumors were observed at various sites including the liver, hematopoietic system, lung and soft tissue. However, at any of the sites, the tumor incidence, the time to death with tumors or the histological distribution of tumors did not differ significantly from those in the untreated control group. Thus, the present study did not demonstrate a tumorigenic effect of SE on B6C3F1 mice by means of oral administration.
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| Keywords |
Tumorigenicity
Sodium elythorbate
Mouse
|
| Descriptions |
This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.
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| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1989-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584058
|
