Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
Hiroshima Journal of Medical Sciences 38 巻 3 号
95-98 頁
1989-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
|
| 作成者 |
Roy Bidyut
Watanabe Hiromitsu
Ito Akihiro
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| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 38 |
| 号 | 3 |
| 開始ページ | 95 |
| 終了ページ | 98 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Cataracts were observed in female F344 rats who intravenously received methylnitrosourea (MNU), a potent carcinogen for multiple organs, in one dose of 50 mg/kg body weight. Induction of cataract 40 weeks after MNU treatment was 41 % whereas no cataract was observed in control rats. The aggregation of βH-crystallin fraction by MNU was studied in vitro. HPLC pattern ofβH-crystallin changed when lens protein was incubated for 24 hrs with MNU. HPLC patterns indicated that MNU induced high molecular weight aggregates ofβH-crystallin. This study conveys some indication about the direct interaction of MNU with lens protein in cataract formation.
|
| 著者キーワード |
Rat
Methylnitrosourea
Cataract
Aggregation of βH-crystallin
|
| 内容記述 |
This work was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1989-09 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584061
|
