Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
Hiroshima Journal of Medical Sciences Volume 38 Issue 3
Page 95-98
published_at 1989-09
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Title ( eng ) |
Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
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Creator |
Roy Bidyut
Watanabe Hiromitsu
Ito Akihiro
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 38 |
Issue | 3 |
Start Page | 95 |
End Page | 98 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
Cataracts were observed in female F344 rats who intravenously received methylnitrosourea (MNU), a potent carcinogen for multiple organs, in one dose of 50 mg/kg body weight. Induction of cataract 40 weeks after MNU treatment was 41 % whereas no cataract was observed in control rats. The aggregation of βH-crystallin fraction by MNU was studied in vitro. HPLC pattern ofβH-crystallin changed when lens protein was incubated for 24 hrs with MNU. HPLC patterns indicated that MNU induced high molecular weight aggregates ofβH-crystallin. This study conveys some indication about the direct interaction of MNU with lens protein in cataract formation.
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Keywords |
Rat
Methylnitrosourea
Cataract
Aggregation of βH-crystallin
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Descriptions |
This work was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 1989-09 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584061
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