Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
Hiroshima Journal of Medical Sciences Volume 38 Issue 3
Page 95-98
published_at 1989-09
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| File | |
| Title ( eng ) |
Induction of Cataract in Methylnitrosourea Treated Fischer (F344) Rats
|
| Creator |
Roy Bidyut
Watanabe Hiromitsu
Ito Akihiro
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 38 |
| Issue | 3 |
| Start Page | 95 |
| End Page | 98 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Cataracts were observed in female F344 rats who intravenously received methylnitrosourea (MNU), a potent carcinogen for multiple organs, in one dose of 50 mg/kg body weight. Induction of cataract 40 weeks after MNU treatment was 41 % whereas no cataract was observed in control rats. The aggregation of βH-crystallin fraction by MNU was studied in vitro. HPLC pattern ofβH-crystallin changed when lens protein was incubated for 24 hrs with MNU. HPLC patterns indicated that MNU induced high molecular weight aggregates ofβH-crystallin. This study conveys some indication about the direct interaction of MNU with lens protein in cataract formation.
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| Keywords |
Rat
Methylnitrosourea
Cataract
Aggregation of βH-crystallin
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| Descriptions |
This work was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1989-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584061
|
