A Monoclonal Anti-platelet Antibody which Recognizes p55 Antigen

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タイトル ( eng )
A Monoclonal Anti-platelet Antibody which Recognizes p55 Antigen
作成者
Takaishi Masatoshi
Murakami Yoshie
Ishioka Shinichi
Yamakido Michio
Tsubokura Tokuo
Fu Shu Man
収録物名
Hiroshima Journal of Medical Sciences
38
1
開始ページ 7
終了ページ 11
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
A monoclonal antibody (MoAb) H229(IgGl) was obtained by fusion between SP2/0, mouse myeloma cell line and spleen cells from BC3Fl mice immunized with HEL, a erythroleukemia cell line. MoAb H229 precipitated a 55 kilodalton(KD) molecule in reduced condition. It reacted with platelets and megakaryocytes, but not with monocytes, granulocytes, lymphocytes, thymocytes, red blood cells (REC), colony-forming units-granulocyte/monocyte (CFU-GM), and burst forming units- erythroid (BFU-E). These findings suggest that MoAb H229 reacts with platelets specifically. However, MoAb H229 did not inhibit platelet aggregation induced by ristocetin, ADP, epinephrine and collagen.
著者キーワード
Monoclonal antibody
Platelet
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 1989-03
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2753747