A Monoclonal Anti-platelet Antibody which Recognizes p55 Antigen
Hiroshima Journal of Medical Sciences Volume 38 Issue 1
Page 7-11
published_at 1989-03
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| File | |
| Title ( eng ) |
A Monoclonal Anti-platelet Antibody which Recognizes p55 Antigen
|
| Creator |
Takaishi Masatoshi
Murakami Yoshie
Ishioka Shinichi
Yamakido Michio
Tsubokura Tokuo
Fu Shu Man
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 38 |
| Issue | 1 |
| Start Page | 7 |
| End Page | 11 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
A monoclonal antibody (MoAb) H229(IgGl) was obtained by fusion between SP2/0, mouse myeloma cell line and spleen cells from BC3Fl mice immunized with HEL, a erythroleukemia cell line. MoAb H229 precipitated a 55 kilodalton(KD) molecule in reduced condition. It reacted with platelets and megakaryocytes, but not with monocytes, granulocytes, lymphocytes, thymocytes, red blood cells (REC), colony-forming units-granulocyte/monocyte (CFU-GM), and burst forming units- erythroid (BFU-E). These findings suggest that MoAb H229 reacts with platelets specifically. However, MoAb H229 did not inhibit platelet aggregation induced by ristocetin, ADP, epinephrine and collagen.
|
| Keywords |
Monoclonal antibody
Platelet
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1989-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2753747
|
