Identification of 5' Regulatory Elements of the PDGF-A Chain Gene, and Interaction with Single-stranded DNA Binding Protein
Hiroshima Journal of Medical Sciences 43 巻 4 号
179-184 頁
1994-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Identification of 5' Regulatory Elements of the PDGF-A Chain Gene, and Interaction with Single-stranded DNA Binding Protein
|
| 作成者 |
Takimoto Yasuo
Kuramoto Atsushi
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 43 |
| 号 | 4 |
| 開始ページ | 179 |
| 終了ページ | 184 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The expression of platelet-derived growth factor (PDGF) is controlled in a very complicated manner. To clarify the mechanism of regulation of the PDGF-A chain gene, deletion analysis of the 5'-flanking region was performed. We identified a positive regulatory element 25 base pairs (bp) upstream of TATAA, a negative element 135 bp upstream, a positive element 223 bp upstream and a negative element further upstream. These regulatory sites of the PDGF-A chain gene may be involved in tissue specificity, developmental regulation, and transformation. In addition, our analysis suggested the presence of a strand non-specific single-stranded DNA binding nuclear protein in the positive regulatory element 25 bp upstream of TATAA.
|
| 著者キーワード |
PDGF-A
5' regulatory elements
single-stranded DNA binding protein
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1994-12 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
