Identification of 5' Regulatory Elements of the PDGF-A Chain Gene, and Interaction with Single-stranded DNA Binding Protein
Hiroshima Journal of Medical Sciences Volume 43 Issue 4
Page 179-184
published_at 1994-12
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| File | |
| Title ( eng ) |
Identification of 5' Regulatory Elements of the PDGF-A Chain Gene, and Interaction with Single-stranded DNA Binding Protein
|
| Creator |
Takimoto Yasuo
Kuramoto Atsushi
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 43 |
| Issue | 4 |
| Start Page | 179 |
| End Page | 184 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The expression of platelet-derived growth factor (PDGF) is controlled in a very complicated manner. To clarify the mechanism of regulation of the PDGF-A chain gene, deletion analysis of the 5'-flanking region was performed. We identified a positive regulatory element 25 base pairs (bp) upstream of TATAA, a negative element 135 bp upstream, a positive element 223 bp upstream and a negative element further upstream. These regulatory sites of the PDGF-A chain gene may be involved in tissue specificity, developmental regulation, and transformation. In addition, our analysis suggested the presence of a strand non-specific single-stranded DNA binding nuclear protein in the positive regulatory element 25 bp upstream of TATAA.
|
| Keywords |
PDGF-A
5' regulatory elements
single-stranded DNA binding protein
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1994-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
