Immunohistochemical Localization of Apolipoprotein E in Renal Amyloidosis

Taniguchi Yoshihiko

Yorioka Noriaki

Yamashita Kazuomi

Oda Hiroaki

Nie Li-Fang

Ye Yeu Xue-Feng

Okushin Sayuri

Nishida Yoji

Kushihata Shigeyuki

Yamakido Michio

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

To clarify the role of apolipoprotein E (apo E) in the formation of amyloid deposits, we examined specimens from 11 patients with renal amyloidosis who underwent renal biopsy by an immunohistochemical method using a monoclonal antibody (murine IgG1). Apo E was distributed in the amyloid deposits of all patients in a pattern similar to that obtained with Congo red staining. Strong positive staining for apo E was found on the amyloid deposits in the glomeruli. These results suggest that apo E is a common constituent of amyloid fibrils and that it may be a useful marker for immunohistochemical studies of systemic amyloidosis including renal amyloidosis.

Apolipoprotein E

Pathological molecular chaperones

Amyloid deposits

医学 [ 490 ]

英語

Hiroshima University Medical Press

[ISSN] 0018-2052

[NCID] AA00664312