Immunohistochemical Localization of Apolipoprotein E in Renal Amyloidosis
Hiroshima Journal of Medical Sciences Volume 45 Issue 1
Page 11-14
published_at 1996-03
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| File | |
| Title ( eng ) |
Immunohistochemical Localization of Apolipoprotein E in Renal Amyloidosis
|
| Creator |
Taniguchi Yoshihiko
Yorioka Noriaki
Yamashita Kazuomi
Oda Hiroaki
Nie Li-Fang
Ye Yeu Xue-Feng
Okushin Sayuri
Nishida Yoji
Kushihata Shigeyuki
Yamakido Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 45 |
| Issue | 1 |
| Start Page | 11 |
| End Page | 14 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
To clarify the role of apolipoprotein E (apo E) in the formation of amyloid deposits, we examined specimens from 11 patients with renal amyloidosis who underwent renal biopsy by an immunohistochemical method using a monoclonal antibody (murine IgG1). Apo E was distributed in the amyloid deposits of all patients in a pattern similar to that obtained with Congo red staining. Strong positive staining for apo E was found on the amyloid deposits in the glomeruli. These results suggest that apo E is a common constituent of amyloid fibrils and that it may be a useful marker for immunohistochemical studies of systemic amyloidosis including renal amyloidosis.
|
| Keywords |
Apolipoprotein E
Pathological molecular chaperones
Amyloid deposits
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1996-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
