Differential Effects of Lipid-soluble Toxins on Sodium Channels and L-type Calcium Channels in Frog Ventricular Cells
Hiroshima Journal of Medical Sciences 46 巻 1 号
43-50 頁
1997-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Differential Effects of Lipid-soluble Toxins on Sodium Channels and L-type Calcium Channels in Frog Ventricular Cells
|
| 作成者 |
Furue Toshiaki
Yakehiro Masuhide
Seyama Issei
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 46 |
| 号 | 1 |
| 開始ページ | 43 |
| 終了ページ | 50 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The effect of grayanotoxin I (GTX I), veratridine and aconitine with either an external or internal concentration of 100 μM on L-type calcium (Ca) channels was studied using the whole cell patch clamp and internal dialysis methods. The experimental conditions for the modification of sodium (Na) channels induced by the internal application of these toxins was determined by showing sustained inward currents with depolarizing repetitive pulses. These toxins failed to generate any change in Ca channels under the same experimental protocol as for Na channels. However, external application of these toxins caused a moderate block of the Ca channels without changing the kinetics.
|
| 著者キーワード |
Na channel
L-type Ca channel
Lipid-soluble toxins
Myocardium
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1997-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
