Differential Effects of Lipid-soluble Toxins on Sodium Channels and L-type Calcium Channels in Frog Ventricular Cells

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Title ( eng )
Differential Effects of Lipid-soluble Toxins on Sodium Channels and L-type Calcium Channels in Frog Ventricular Cells
Creator
Furue Toshiaki
Yakehiro Masuhide
Seyama Issei
Source Title
Hiroshima Journal of Medical Sciences
Volume 46
Issue 1
Start Page 43
End Page 50
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
The effect of grayanotoxin I (GTX I), veratridine and aconitine with either an external or internal concentration of 100 μM on L-type calcium (Ca) channels was studied using the whole cell patch clamp and internal dialysis methods. The experimental conditions for the modification of sodium (Na) channels induced by the internal application of these toxins was determined by showing sustained inward currents with depolarizing repetitive pulses. These toxins failed to generate any change in Ca channels under the same experimental protocol as for Na channels. However, external application of these toxins caused a moderate block of the Ca channels without changing the kinetics.
Keywords
Na channel
L-type Ca channel
Lipid-soluble toxins
Myocardium
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1997-03
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312