TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection
Hiroshima Journal of Medical Sciences Volume 62 Issue 2
Page 31-37
published_at 2013-06
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Title ( eng ) |
TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection
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Creator |
Naychov Zheko Dimirtov
Uchida Naomichi
Delchev Konstantin Vassilev
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 62 |
Issue | 2 |
Start Page | 31 |
End Page | 37 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD.
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Keywords |
Aortic dissection
SNP
TIMP-1
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 2013-06 |
Rights |
(c) Hiroshima University Medical Press.
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Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
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