Regression of a Primary Pulmonary Adenocarcinoma after Zoledronic Acid Monotherapy

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タイトル ( eng )
Regression of a Primary Pulmonary Adenocarcinoma after Zoledronic Acid Monotherapy
作成者
Nagao Saeko
Hattori Noboru
Kanehara Masashi
Ishikawa Nobuhisa
収録物名
Hiroshima Journal of Medical Sciences
60
1
開始ページ 7
終了ページ 9
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Bisphosphonates are widely used for the treatment of metastatic skeletal tumors and hypercalcemia resulting from malignant tumors. Zoledronic acid (ZOL), a third-generation bisphosphonate agent, was recently demonstrated to show synergistic antitumor activity of ZOL when combined with chemotherapy in lung cancer patients. However, whether ZOL exerts direct antitumor activity on lung cancer remains unclear. Here, we report an atypical case encountered while treating a 57-year-old woman with pulmonary adenocarcinoma and multiple metastases of the liver, left adrenal gland, and bone. The nonskeletal lesions, consisting of the primary lesion and hepatic metastasis, regressed after treatment with ZOL alone. We believe this case demonstrates a possible antitumor effect of ZOL against lung cancer.
著者キーワード
Lung cancer
Bone metastasis
Zoledronic acid
Anti-tumor effect
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 2011-03
権利情報
(c) Hiroshima University Medical Press.
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312