Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma

Digestive Diseases and Sciences 53 巻 8 号 2281-2286 頁 2008-08 発行
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タイトル ( eng )
Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma
作成者
Uemura Kenichiro
Hayashidani Yasuo
Shimamoto Fumio
収録物名
Digestive Diseases and Sciences
53
8
開始ページ 2281
終了ページ 2286
抄録
Purpose: The aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma.

Methods: The records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed.

Results: A 98% rate of potentially curative (R0) resection was achieved. There was no 30-day mortality. Overall 5-year survival rate was 64%.0 Univariate analysis revealed that T3 and T4 tumor (ie, pancreatic parenchymal invasion) (P<0.001), lymph node metastasis (P=0.01), and perineural invasion (P<0.001) were significant predictors of poor prognosis. Furthermore, perineural invasion was found to be a significant independent predictor of poor prognosis by multivariate analysis (P=0.024).

Conclusions: Pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma is a safe surgical procedure with an acceptable cure rate. The presence of perineural invasion may be useful for predicting poor prognosis in patients with ampullary carcinoma who undergo potentially curative resection.
著者キーワード
ampullary carcinoma
prognostic factor
perineural invasion
pancreatoduodenectomy
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Springer Netherlands
発行日 2008-08
権利情報
Copyright (c) 2008 Springer
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
The original publication is available at www.springerlink.com
[ISSN] 0163-2116
[DOI] 10.1007/s10620-007-0117-6
[NCID] AA00161107
[DOI] http://dx.doi.org/10.1007/s10620-007-0117-6