Health-related quality of life after sustained virological response to treatment for hepatitis C
Hiroshima Journal of Medical Sciences 73 巻 1-2 号
1-7 頁
2024-06 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Health-related quality of life after sustained virological response to treatment for hepatitis C
|
| 作成者 |
MASUMOTO Fumi
Bunthen E
SEIKE Masataka
AKUTA Norio
KUMADA Takashi
KARINO Yoshiyasu
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 73 |
| 号 | 1-2 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ページ数 | 7 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| 抄録 |
This study aimed to show the changes in health-related quality of life (HRQoL) after a sustained virological response (SVR) to hepatitis C treatment. A retrospective study was conducted among 1,546 patients with SVR to interferon-based (IFN-based) or direct-acting antiviral (DAA) anti hepatitis C virus treatments from January 1990 to March 2017 in five hospitals. The survey was conducted between November 2017 and October 2018. A questionnaire including the Japanese version of the EQ-5D-3L before and after SVR by IFN-based or DAA treatment was used to assess changes in HRQoL retrospectively. Of the 1,546 patients who achieved SVR, 580 achieved SVR with IFN-based treatment (SVR-IFN) and 966 achieved SVR with DAA treatment (SVR-DAA). Comparison of HRQoL before and after treatment revealed a significant increase in SVR-IFN (0.9078 vs. 0.9278, p = 0.0406). For SVR-IFN, patients in their 60s and 70s showed a significant increase in HRQoL after treatment. In contrast, changes in HRQoL in SVR-DAA were not statistically significant (0.9018 vs. 0.9063, p = 0.3908). For SVR-DAA, HRQoL significantly improved for patients in their 50s and 60s. The results of this study showed a trend toward improvement or unchanged HRQoL in patients who achieved SVR, despite advanced age. The results of this study can serve as a basis for follow-up after SVR and cost-effectiveness analyses.
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| 著者キーワード |
Hepatitis C
Interferons
Japan
Quality of Life
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 2024-06 |
| 権利情報 |
Copyright (c) 2024 Hiroshima University Medical Press
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 助成機関名 |
日本医療研究開発機構
Japan Agency for Medical Research and Development (AMED)
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| 助成機関識別子 |
[Crossref Funder] https://doi.org/10.13039/100009619
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| 研究課題名 | |
| 研究課題番号 |
17fk0210104h0001
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