Effect of COVID-19 vaccination on viral clearance and antibody production in older patients with SARS-CoV-2 infection
Hiroshima Journal of Medical Sciences 71 巻 3-4 号
45-50 頁
2022-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Effect of COVID-19 vaccination on viral clearance and antibody production in older patients with SARS-CoV-2 infection
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| 作成者 |
ITO Noriaki
KITAHARA Yoshihiro
MIWATA Kei
OKIMOTO Mafumi
TAKAFUTA Toshiro
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 71 |
| 号 | 3-4 |
| 開始ページ | 45 |
| 終了ページ | 50 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| 抄録 |
Whether coronavirus disease 2019 (COVID-19) vaccination promotes viral clearance in older patients has not been reported. We performed a retrospective review of patients hospitalized with COVID-19. This study included 24 patients with COVID-19 admitted to Hiroshima City Funairi Citizens Hospital between June 1 and July 10, 2021. Nine patients who were vaccinated (median age: 72 years) were compared with 15 patients who were not vaccinated (median age: 70 years). Viral clearance was confirmed by SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR). Antibody titers were measured to assess vaccination efficacy. The vaccinated group had a higher negative conversion rate than that in the non-vaccinated group on RT-PCR testing before discharge (83% vs. 36%, P = 0.064). Antibody titers on admission and 10 ± 2 days after onset were significantly higher in the vaccinated group than those in the non-vaccinated group (35 vs. 0 binding antibody units (BAU)/mL, P = 0.012; and 114 vs. 7 BAU/mL, P = 0.032, respectively). Stimulating antibody production by vaccination may promote faster viral clearance in older patients who develop COVID-19.
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| 著者キーワード |
COVID-19
Older patients
Vaccine
Viral clearance
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| 内容記述 |
This research was funded by “Advanced study aim to contribute creating new evidence in COVID-19 based on the local government-academia collaboration research system in Hiroshima”: AMED Research Program on Emerging and Re-emerging Infectious Diseases, Grant Number JP20fk0108453.
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
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| 発行日 | 2022-12 |
| 権利情報 |
Copyright (c) 2022 Hiroshima University Medical Press
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
|
