Effect of COVID-19 vaccination on viral clearance and antibody production in older patients with SARS-CoV-2 infection
Hiroshima Journal of Medical Sciences Volume 71 Issue 3-4
Page 45-50
published_at 2022-12
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| File | |
| Title ( eng ) |
Effect of COVID-19 vaccination on viral clearance and antibody production in older patients with SARS-CoV-2 infection
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| Creator |
ITO Noriaki
KITAHARA Yoshihiro
MIWATA Kei
OKIMOTO Mafumi
TAKAFUTA Toshiro
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| Source Title |
Hiroshima Journal of Medical Sciences
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| Volume | 71 |
| Issue | 3-4 |
| Start Page | 45 |
| End Page | 50 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
Whether coronavirus disease 2019 (COVID-19) vaccination promotes viral clearance in older patients has not been reported. We performed a retrospective review of patients hospitalized with COVID-19. This study included 24 patients with COVID-19 admitted to Hiroshima City Funairi Citizens Hospital between June 1 and July 10, 2021. Nine patients who were vaccinated (median age: 72 years) were compared with 15 patients who were not vaccinated (median age: 70 years). Viral clearance was confirmed by SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR). Antibody titers were measured to assess vaccination efficacy. The vaccinated group had a higher negative conversion rate than that in the non-vaccinated group on RT-PCR testing before discharge (83% vs. 36%, P = 0.064). Antibody titers on admission and 10 ± 2 days after onset were significantly higher in the vaccinated group than those in the non-vaccinated group (35 vs. 0 binding antibody units (BAU)/mL, P = 0.012; and 114 vs. 7 BAU/mL, P = 0.032, respectively). Stimulating antibody production by vaccination may promote faster viral clearance in older patients who develop COVID-19.
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| Keywords |
COVID-19
Older patients
Vaccine
Viral clearance
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| Descriptions |
This research was funded by “Advanced study aim to contribute creating new evidence in COVID-19 based on the local government-academia collaboration research system in Hiroshima”: AMED Research Program on Emerging and Re-emerging Infectious Diseases, Grant Number JP20fk0108453.
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| Language |
eng
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| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 2022-12 |
| Rights |
Copyright (c) 2022 Hiroshima University Medical Press
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
|
