Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information
Clinical & Medical Biochemistry 6 巻 3 号
2020-10-26 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information
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| 作成者 |
Kurihara Kensuke
Toyota Taro
Suzuki Kentaro
Sugawara Tadashi
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| 収録物名 |
Clinical & Medical Biochemistry
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| 巻 | 6 |
| 号 | 3 |
| 抄録 |
In the prebiotic era, physicochemical cause and effect served as the primitive flow of information for protocells. Our recent study claimed that the manners and frequencies of self-reproduction of giant vesicle (GV) -based model protocells were regulated by the incorporated DNA-length, and not the base-pair sequence due to the presence of a supramolecular catalyst (lipo-deoxyribozyme) composed of DNA and lipophilic catalysts. The DNA-length dependent dynamics of the self-reproducing GVs containing different length of DNA were examined by three independent experiments; Population analysis by flow cytometric measurements, counting of increased numbers of protocells and direct morphological observation of a single GV by confocal microscopy. These results may shed light on the information system in the prebiotic stage, when the central dogma was not established. Notably, recent reports have revealed the possible influence of DNA length on the activation of living cells through the complexation of DNA to an enzyme in non-sequential aggregation manner.
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| 著者キーワード |
Protocell
Self-reproduction
DNA-chain length
Primitive flow of information
Physicochemical causes and effects
Morphological change
Lipo-deoxyribozyme
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| 内容記述 |
This work was supported by JSPS KAKENHI (Grant Numbers JP25103009, JP16K05759 and JP17H04876), ‘Platform for Dynamic Approaches to Living System’ at the University of Tokyo, Kanagawa University Grant for Joint Research, and the Yoshida Scholarship Foundation.
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Longdom Publishing
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| 発行日 | 2020-10-26 |
| 権利情報 |
© 2020 Matsuo M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 2471-2663
[DOI] 10.35248/2471-2663.20.06.150
[DOI] https://doi.org/10.35248/2471-2663.20.06.150
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