Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information
Clinical & Medical Biochemistry Volume 6 Issue 3
published_at 2020-10-26
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| File | |
| Title ( eng ) |
Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information
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| Creator |
Kurihara Kensuke
Toyota Taro
Suzuki Kentaro
Sugawara Tadashi
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| Source Title |
Clinical & Medical Biochemistry
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| Volume | 6 |
| Issue | 3 |
| Abstract |
In the prebiotic era, physicochemical cause and effect served as the primitive flow of information for protocells. Our recent study claimed that the manners and frequencies of self-reproduction of giant vesicle (GV) -based model protocells were regulated by the incorporated DNA-length, and not the base-pair sequence due to the presence of a supramolecular catalyst (lipo-deoxyribozyme) composed of DNA and lipophilic catalysts. The DNA-length dependent dynamics of the self-reproducing GVs containing different length of DNA were examined by three independent experiments; Population analysis by flow cytometric measurements, counting of increased numbers of protocells and direct morphological observation of a single GV by confocal microscopy. These results may shed light on the information system in the prebiotic stage, when the central dogma was not established. Notably, recent reports have revealed the possible influence of DNA length on the activation of living cells through the complexation of DNA to an enzyme in non-sequential aggregation manner.
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| Keywords |
Protocell
Self-reproduction
DNA-chain length
Primitive flow of information
Physicochemical causes and effects
Morphological change
Lipo-deoxyribozyme
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| Descriptions |
This work was supported by JSPS KAKENHI (Grant Numbers JP25103009, JP16K05759 and JP17H04876), ‘Platform for Dynamic Approaches to Living System’ at the University of Tokyo, Kanagawa University Grant for Joint Research, and the Yoshida Scholarship Foundation.
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Longdom Publishing
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| Date of Issued | 2020-10-26 |
| Rights |
© 2020 Matsuo M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 2471-2663
[DOI] 10.35248/2471-2663.20.06.150
[DOI] https://doi.org/10.35248/2471-2663.20.06.150
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