Self-healing polyurethane elastomers based on charge-transfer interactions for biomedical applications
Polymer Journal Volume 53
Page 355-362
published_at 2020-10-22
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| File | |
| Title ( eng ) |
Self-healing polyurethane elastomers based on charge-transfer interactions for biomedical applications
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| Creator |
Nakajima Hidekazu
Yamanaka Ryota
Takeda Naoya
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| Source Title |
Polymer Journal
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| Volume | 53 |
| Start Page | 355 |
| End Page | 362 |
| Abstract |
One promising application of self-healing polymeric materials is biomedical use. Although charge-transfer (CT) interactions have been employed to construct self-healing polymers as well as other reversible bonds and interactions, their potential for biomedical applications has never been investigated. In this study, we fabricated self-healable and cell-compatible polyurethane elastomers cross-linked by CT complexes between electron-rich pyrene (Py) and electron-deficient naphthalene diimide (NDI) by simply blending two linear polymers with Py or NDI as a repeating unit. The elastomers with different blend ratios self-healed damage over 1 day in mild conditions, including in air and water at 30–100 °C. The mechanical properties of damaged elastomers were almost restored after healing in air at 100 °C, and even in air at 30 °C and in water at 70 °C, healing was also possible to a certain extent. The good cell compatibility of the polyurethane elastomers was demonstrated by culturing two kinds of cells on the thin film substrates.
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| Keywords |
biomaterial
cell culture scaffold
charge-transfer interaction
elastomer
selfhealing
supramolecular chemistry
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| Descriptions |
This work was supported by JSPS KAKENHI (Grant No. 16H07292 and 19K15623, KI), MEXT LEADER (Grant No. A6501, KI), and the Izumi Science and Technology Foundation (Grant No. H29-J-113, KI). A research grant from the Mitsubishi Materials–Faculty of Science and Engineering, Waseda University (2016, 2018) and a Grant for Young Scientists Encouragement from the Waseda Research Institute for Science and Engineering–JXTG Energy (2017) are also acknowledged for financial support.
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Springer Nature
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| Date of Issued | 2020-10-22 |
| Rights |
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0032-3896
[ISSN] 1349-0540
[DOI] 10.1038/s41428-020-00432-4
[DOI] https://doi.org/10.1038/s41428-020-00432-4
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