Immunohistochemical Analysis of Colorectal Cancer among Atomic Bomb Survivors in Hiroshima

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Title ( eng )
Immunohistochemical Analysis of Colorectal Cancer among Atomic Bomb Survivors in Hiroshima
Creator
YAMAMOTO Masami
YAMAMOTO Tetsuro
HATA Jotaro
NAKAGAWA Hitoshi
NAKATSUKA Hirofumi
TAHARA Eiichi
Source Title
Hiroshima Journal of Medical Sciences
Volume 36
Issue 4
Start Page 387
End Page 393
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
In order to elucidate the biological characteristics of colorectal cancer among atomic bomb survivors in Hiroshima, a total of 159 cases of colorectal cancers comprising 73 cases in exposed atomic bomb survivors and 86 cases in non-exposed individuals were examined histologically and immunohistochemically for various functioning proteins. No statistical differences could be demonstrated in the incidence of various marker expressions of colorectal cancers between the exposed group and control group. However, comparison by the site of colorectal cancer showed that sigmoid colon cancers in the exposed group or high dose group showed a significantly higher frequency of glycoproteins such as α1-antichymotrypsin (ACT), secretory component (SC), α1-antitrypsin (AAT), and human chorionic gonadotropin (HCG) when compared with the control group. These results correlated well with the epidemiological data that the radiation effect on the incidence of colorectal cancer in atomic bomb survivors was most remarkable in the sigmoid colon.
Keywords
Colorectal cancer
Atomic bomb survivors
Immunohistochemistry
Descriptions
This study was supported in part by Grants in Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1987-12
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3448061