Immunohistochemical Analysis of Colorectal Cancer among Atomic Bomb Survivors in Hiroshima
Hiroshima Journal of Medical Sciences Volume 36 Issue 4
Page 387-393
published_at 1987-12
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| File | |
| Title ( eng ) |
Immunohistochemical Analysis of Colorectal Cancer among Atomic Bomb Survivors in Hiroshima
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| Creator |
YAMAMOTO Masami
YAMAMOTO Tetsuro
HATA Jotaro
NAKAGAWA Hitoshi
NAKATSUKA Hirofumi
TAHARA Eiichi
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 4 |
| Start Page | 387 |
| End Page | 393 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
In order to elucidate the biological characteristics of colorectal cancer among atomic bomb survivors in Hiroshima, a total of 159 cases of colorectal cancers comprising 73 cases in exposed atomic bomb survivors and 86 cases in non-exposed individuals were examined histologically and immunohistochemically for various functioning proteins. No statistical differences could be demonstrated in the incidence of various marker expressions of colorectal cancers between the exposed group and control group. However, comparison by the site of colorectal cancer showed that sigmoid colon cancers in the exposed group or high dose group showed a significantly higher frequency of glycoproteins such as α1-antichymotrypsin (ACT), secretory component (SC), α1-antitrypsin (AAT), and human chorionic gonadotropin (HCG) when compared with the control group. These results correlated well with the epidemiological data that the radiation effect on the incidence of colorectal cancer in atomic bomb survivors was most remarkable in the sigmoid colon.
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| Keywords |
Colorectal cancer
Atomic bomb survivors
Immunohistochemistry
|
| Descriptions |
This study was supported in part by Grants in Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
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| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
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| Date of Issued | 1987-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3448061
|
