The Synergistic Antitumor Effect of Natural-Human TNF and Anticancer Drugs

ITANO Satoshi

FUCHIMOTO Sadanori

ORITA Kunzo

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

In the present report, we compared and discussed synergistic antitumor effects of natural-human tumor necrosis factor (n-TNF) which was derived from human acute lymphoblastic leukemia BALL-I cells and conventional anticancer drugs by using Lewis lung carcinoma which was transplanted on BDF1 mice. n-TNF and anticancer drugs were administered daily for 10 days. n-TNF showed antitumor effects which were equivalent to or stronger than MMC (1 mg/kg/day, i.v.), 5FU (5 mg/kg/day, i.v.), Adriamycin (1 mg/kg/day, i.v.), Actinomycin D (0.05 mg/kg/day, i.v.), Cyclophosphamide (10 mg/kg/day, i.v.) and OK-432 (0.5 KE/mouse/day, s.c.).
And synergistic antitumor effects were observed when n-TNF was administered with anticancer drugs, and the strong enforcement was obtained especially when it was combined with 5FU.

Natural human TNF

Lymphokine

Anticancer drugs

Synergistic effect

医学 [ 490 ]

英語

Hiroshima Journal Medical Press

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3654267