The Synergistic Antitumor Effect of Natural-Human TNF and Anticancer Drugs
Hiroshima Journal of Medical Sciences Volume 36 Issue 2
Page 157-161
published_at 1987-06
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| File | |
| Title ( eng ) |
The Synergistic Antitumor Effect of Natural-Human TNF and Anticancer Drugs
|
| Creator |
ITANO Satoshi
FUCHIMOTO Sadanori
ORITA Kunzo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 2 |
| Start Page | 157 |
| End Page | 161 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
In the present report, we compared and discussed synergistic antitumor effects of natural-human tumor necrosis factor (n-TNF) which was derived from human acute lymphoblastic leukemia BALL-I cells and conventional anticancer drugs by using Lewis lung carcinoma which was transplanted on BDF1 mice. n-TNF and anticancer drugs were administered daily for 10 days. n-TNF showed antitumor effects which were equivalent to or stronger than MMC (1 mg/kg/day, i.v.), 5FU (5 mg/kg/day, i.v.), Adriamycin (1 mg/kg/day, i.v.), Actinomycin D (0.05 mg/kg/day, i.v.), Cyclophosphamide (10 mg/kg/day, i.v.) and OK-432 (0.5 KE/mouse/day, s.c.).
And synergistic antitumor effects were observed when n-TNF was administered with anticancer drugs, and the strong enforcement was obtained especially when it was combined with 5FU. |
| Keywords |
Natural human TNF
Lymphokine
Anticancer drugs
Synergistic effect
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima Journal Medical Press
|
| Date of Issued | 1987-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3654267
|
