Decomposition of Sevoflurane by Sodalime
Hiroshima Journal of Medical Sciences 36 巻 1 号
61-67 頁
1987-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Decomposition of Sevoflurane by Sodalime
|
| 作成者 |
HANAKI Chihiro
FUJII Kohyu
MORIO Michio
TASHIMA Toshio
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 36 |
| 号 | 1 |
| 開始ページ | 61 |
| 終了ページ | 67 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Stability of sevoflurane (fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether), a new inhalational anesthetic, in sodalime was examined, and the products of their reaction were identified and quantitated.
Five reaction products were identified: fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a dehydrofluorination product of sevoflurane which is contained as an impurity in sevoflurane preparations, fluoromethyl 2-methoxy-2,2-difluoro-1-(trifluoromethyl)ethyl ether, a methylation product of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and/or sevoflurane, fluoromethyl 2-methoxy-2,2-difluoro-1-(difluoromethylene)ethyl ether and two isomers of fluoromethyl 2-methoxy-2-fluoro-1-(trifluoromethyl)vinyl ether, dehydrofluorination products of fluoromethyl 2-methoxy-2,2-difluoro-1-(trifluoromethyl)ethyl ether. In a closed anesthetic circuit with sodalime connected to a model lung, fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether increased and reached a plateau. Fluoromethyl 2-methoxy-2,2-difluoro-1-(trifluoromethyl)ethyl ether increased linearly and other substances were detected only in a trace amount. In the semi-closed anesthetic circuit with sodalime supplied with 6 liters/min fresh gas flow, no reaction products were detected except fluoromethyl 2,2-difluoro-1- (trifluoromethyl)vinyl ether, which showed a maximum concentration of 2 and 4 ppm when the feeding concentration of sevoflurane was 1.7 and 2.7%, respectively. It is known that fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether is a weak anesthetic with AC_50 =3.58%, LC_50 =10.17% and AI=2.84. These results indicate that sevoflurane can be used with sodalime in a semi-closed anesthetic circuit. |
| 著者キーワード |
Sevoflurane
Sodalime
Decomposition
Stability
|
| 内容記述 |
This study was supported in part by a Grant-in-aid for Science Research from the Ministry of Education, Science and Culture of Japan and a Grant-in-aid from the Association for the Advancement of Medicine of the Tsuchiya Foundation.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1987-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3583805
|
