Experimental Model of Gastritis Induced by Sodium Taurocholate in Rats
Hiroshima Journal of Medical Sciences Volume 35 Issue 2
Page 143-147
published_at 1986-06
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| File | |
| Title ( eng ) |
Experimental Model of Gastritis Induced by Sodium Taurocholate in Rats
|
| Creator |
KISHIMOTO Shinya
OGAWA Mitsuyo
TAKABA Norio
KAMBARA Akihiko
OKAMOTO Kazuma
SHIMIZU Satoru
KUNITA Toshio
DAITOKU Kunihiko
KAJIYAMA Goro
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 2 |
| Start Page | 143 |
| End Page | 147 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Experimental gastritis was produced in rats by administration of sodium taurocholate (5 mM) for 3 months. The gastritis was associated with mucosal surface injury (erosion), inflammatory cell infiltration and proliferation of interstitial fibrosis in the gastric mucosa. The number of parietal cells per unit area and the mucosal thickness, however, were not different from those in the normal mucosa, indicating that this kind of gastritis was not atrophic but erosive gastritis. The model of erosive gastritis is most useful in studies on gastroprotection and various drugs.
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| Keywords |
Gastritis
Taurocholic acid
Erosion
Fibrosis
Parietal cells
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3771272
|
