Detection of Lymphocyte Subsets by Monoclonal Antibodies in Aged and Young Humans

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Title ( eng )
Detection of Lymphocyte Subsets by Monoclonal Antibodies in Aged and Young Humans
Creator
YAMAKIDO Michio
YANAGIDA Jitsuro
ISHIOKA Shinichi
MATSUZAKA Shigeru
HOZAWA Soichiro
AKIYAMA Mitoshi
KOBUKE Kyoko
INAMIZU Tsutomu
NISHIMOTO Yukio
Source Title
Hiroshima Journal of Medical Sciences
Volume 34
Issue 1
Start Page 87
End Page 94
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
With the use of Leu-series monoclonal antibodies, peripheral blood lymphocyte subsets in aged and young humans were determined.
1) In comparison with young individuals, Leu-1+ cells and Leu-2a+ cells were decreased, whereas Leu-7+ cells and Leu-3a/Leu-2a were increased in aged individuals.
2) No sex difference could be observed in lymphocyte subsets.
3) PHA response of lymphocytes showed a negative correlation with Leu-2a+ cells and a positive correlation with Leu-3a/Leu-2a in aged individuals.
Keywords
Lymphocyte subset
Monoclonal antibody
Leu series
Aging
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University School of Medicine
Date of Issued 1985-03
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3926724