A model for how fission yeast cells scale their size with ploidy

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Title ( eng )
A model for how fission yeast cells scale their size with ploidy
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Abstract
It has long been known that eukaryotic cells with more DNA content are larger in cell size. However, no molecular mechanisms for this universal rule have been given. In the fission yeast Schizosaccharomyces pombe, diploid cells grow faster at 1.5-fold rate than haploid cells during the same cycle time. Here I discovered that cell division genes control not only cell growth or cell extension rate (CER) but also cycle time dose-dependently in diploid cells. These genes are well-known regulators for Cdc2, a conserved master regulator of eukaryotic cell cycle, such as inhibitors (wee1+ and pom1+) and activators (cdc25+ and nim1+). Actin content and its dynamics between monomer and polymer forms also control CER and cycle time through nuclear accumulation of Wee1 and Cdc25. Remarkably, doubling these genes in haploids reproduced CER of diploids. I propose a model in which regulatory cascades for Cdc2 activity govern the cell-size scaling with ploidy.
Keywords
actin
cdc25
nim1
ploidy
scaling
wee1
Language
eng
Resource Type other
Rights
© Copyright by Ichiro Yamashita 2020
Publish Type Author’s Original
Access Rights open access
Date
[Created] 2020-04-28
Remark 未発表原稿