Association between resistance-associated NS5A variants of hepatitis C virus and efficacy of direct-acting antivirals in human hepatocyte transplanted mice 1) Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice 2) Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure

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Title ( eng )
Association between resistance-associated NS5A variants of hepatitis C virus and efficacy of direct-acting antivirals in human hepatocyte transplanted mice 1) Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice 2) Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure
Title ( jpn )
ヒト肝細胞キメラマウスを用いたNS5A阻害薬耐性変異型HCVとDAA療法の関連性の研究 1) NS5A阻害薬治療不成功例におけるNS5A耐性関連変異およびヒト肝細胞キメラマウスを用いたNS5A-P32欠失変異を持つC型肝炎ウイルスに対する有効な治療法の検討 2) NS5A阻害薬治療不成功例におけるダクラタスビル/アスナプレビル/ベクラブビル治療の問題点について
Creator
Teraoka Yuji
Language
eng
Resource Type doctoral thesis
Rights
(c) 2018 Elsevier Inc. All rights reserved.
(c) 2018 The Authors
Access Rights open access
Source Identifier
Biochemical and Biophysical Research Communications 500 (2018) 152e157
Teraoka et al., Journal of General Virology 2018;99:1058-1065
[DOI] https://doi.org/10.1016/j.bbrc.2018.04.005
[DOI] https://doi.org/10.1099/jgv.0.001091
Dissertation Number 甲第7998号
Degree Name
Date of Granted 2019-09-20
Degree Grantors
広島大学
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