Photodynamic Activities of Porphyrin Derivative–Cyclodextrin Complexes by Photoirradiation
ACS Medicinal Chemistry Letters 8 巻 5 号
555-559 頁
2017-05-11 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Photodynamic Activities of Porphyrin Derivative–Cyclodextrin Complexes by Photoirradiation
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| 作成者 |
Satake Shuhei
Mae Tomoya
Shigeto Hajime
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| 収録物名 |
ACS Medicinal Chemistry Letters
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| 巻 | 8 |
| 号 | 5 |
| 開始ページ | 555 |
| 終了ページ | 559 |
| 抄録 |
Water-soluble cyclodextrin (CyD)-complexed with porphyrin derivatives with different substituents in the mesopositions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step towards the optimization of porphyrin derivatives as photosensitizers.
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| 著者キーワード |
porphyrin
cyclodextrin
photodynamic therapy
photosensitizer
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| 内容記述 |
Supporting Information is available free of charge on the ACS Publications website.
Experimental procedures and UV-vis absorption and NMR spectra (PDF). This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982) and the Electric Technology Research Foundation of Chugoku.
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| NDC分類 |
化学 [ 430 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
American Chemical Society
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| 発行日 | 2017-05-11 |
| 権利情報 |
Copyright (c) 2017 American Chemical Society
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'ACS Medicinal Chemistry Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmedchemlett.7b00098.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 1948-5875
[DOI] 10.1021/acsmedchemlett.7b00098
[PMID] 28523110
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