Photodynamic Activities of Porphyrin Derivative–Cyclodextrin Complexes by Photoirradiation
ACS Medicinal Chemistry Letters Volume 8 Issue 5
Page 555-559
published_at 2017-05-11
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| File | |
| Title ( eng ) |
Photodynamic Activities of Porphyrin Derivative–Cyclodextrin Complexes by Photoirradiation
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| Creator |
Satake Shuhei
Mae Tomoya
Shigeto Hajime
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| Source Title |
ACS Medicinal Chemistry Letters
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| Volume | 8 |
| Issue | 5 |
| Start Page | 555 |
| End Page | 559 |
| Abstract |
Water-soluble cyclodextrin (CyD)-complexed with porphyrin derivatives with different substituents in the mesopositions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step towards the optimization of porphyrin derivatives as photosensitizers.
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| Keywords |
porphyrin
cyclodextrin
photodynamic therapy
photosensitizer
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| Descriptions |
Supporting Information is available free of charge on the ACS Publications website.
Experimental procedures and UV-vis absorption and NMR spectra (PDF). This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982) and the Electric Technology Research Foundation of Chugoku.
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| NDC |
Chemistry [ 430 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
American Chemical Society
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| Date of Issued | 2017-05-11 |
| Rights |
Copyright (c) 2017 American Chemical Society
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'ACS Medicinal Chemistry Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmedchemlett.7b00098.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 1948-5875
[DOI] 10.1021/acsmedchemlett.7b00098
[PMID] 28523110
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