Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages

Chemistry - An Asian Journal 12 巻 10 号 1069-1074 頁 2017-05-18 発行
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タイトル ( eng )
Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages
作成者
Iizuka Tatsuya
Maekubo Naotake
Nobusawa Kazuyuki
Koumoto Kazuya
Suzuki Toshio
Nagasaki Takeshi
Akiyama Motofusa
収録物名
Chemistry - An Asian Journal
12
10
開始ページ 1069
終了ページ 1074
抄録
Anionic and neutral fullerene derivatives were dissolved in water by β-(1,3-1,6)-D-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ca. 0.30 mM and the average particle sizes were ca. 90 nm. The β-1,3-glucan complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ > 610 nm) when compared with that of other β-1,3-glucan-complexed fullerene derivatives. This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with β-1,3-glucan-receptors on the surface of macrophages when β-1,3-glucan is recognized. In contrast, all β-1,3-glucan complexed fullerene derivatives showed no photodynamic activity toward HeLa cells under the same conditions.
著者キーワード
fullerenes
host-guest chem.
macrophage
medicinal chem.
polysaccharides
内容記述
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
NDC分類
化学 [ 430 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Wiley-VCH
発行日 2017-05-18
権利情報
Copyright (c) 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is the peer reviewed version of the following article: A. Ikeda, T. Iizuka, N. Maekubo, K. Nobusawa, K. Sugikawa, K. Koumoto, T. Suzuki, T. Nagasaki, M. Akiyama, Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages, Chem.-Asian J., 12, 1069–1074, 2017, which has been published in final form at https://doi.org/10.1002/asia.201700182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 1861-4728
[ISSN] 1861-471X
[DOI] 10.1002/asia.201700182
[PMID] 28266184