Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages
Chemistry - An Asian Journal Volume 12 Issue 10
Page 1069-1074
published_at 2017-05-18
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| File | |
| Title ( eng ) |
Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages
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| Creator |
Iizuka Tatsuya
Maekubo Naotake
Nobusawa Kazuyuki
Koumoto Kazuya
Suzuki Toshio
Nagasaki Takeshi
Akiyama Motofusa
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| Source Title |
Chemistry - An Asian Journal
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| Volume | 12 |
| Issue | 10 |
| Start Page | 1069 |
| End Page | 1074 |
| Abstract |
Anionic and neutral fullerene derivatives were dissolved in water by β-(1,3-1,6)-D-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ca. 0.30 mM and the average particle sizes were ca. 90 nm. The β-1,3-glucan complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ > 610 nm) when compared with that of other β-1,3-glucan-complexed fullerene derivatives. This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with β-1,3-glucan-receptors on the surface of macrophages when β-1,3-glucan is recognized. In contrast, all β-1,3-glucan complexed fullerene derivatives showed no photodynamic activity toward HeLa cells under the same conditions.
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| Keywords |
fullerenes
host-guest chem.
macrophage
medicinal chem.
polysaccharides
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| Descriptions |
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
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| NDC |
Chemistry [ 430 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Wiley-VCH
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| Date of Issued | 2017-05-18 |
| Rights |
Copyright (c) 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is the peer reviewed version of the following article: A. Ikeda, T. Iizuka, N. Maekubo, K. Nobusawa, K. Sugikawa, K. Koumoto, T. Suzuki, T. Nagasaki, M. Akiyama, Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages, Chem.-Asian J., 12, 1069–1074, 2017, which has been published in final form at https://doi.org/10.1002/asia.201700182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 1861-4728
[ISSN] 1861-471X
[DOI] 10.1002/asia.201700182
[PMID] 28266184
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