HISTAMINASE AND ITS INHIBITORY FACTOR IN GUINEA PIG SKIN

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タイトル ( eng )
HISTAMINASE AND ITS INHIBITORY FACTOR IN GUINEA PIG SKIN
タイトル ( jpn )
モルモット皮膚のヒスタミナーゼとその阻害因子
作成者
Yamamoto Shoso
収録物名
Hiroshima Journal of Medical Sciences
30
3
開始ページ 251
終了ページ 254
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
The crude histaminase preparation obtained from guinea pig skin was fractionated by Sephadex G-200 at 4°C and 55°C. The histaminase activity corresponded to the descending limb of the first peak of protein eluted just after void volume at 4°C and to the second peak at 55°C. The histaminase activity in the fractions eluted at 4°C was higher at 55°C than at 37°C. On the contrary, no significant difference between the histaminase activity assayed at 55°C and 37°C was observed in the fractions eluted at 55°C. On Sephadex G-200 gel filtration, histaminase was eluted in the later fractions at 55°C, compared with the fractions eluted at 4°C, indicating that the molecular weight of histaminase may become smaller at 55°C. These facts suggest that histaminase obtained from guniea pig skin may bind with an inhibitor-like substance at low temperature and that the enzyme may separate from the inhibitor at high temperature.
内容記述
This work was supported in part by Scientific Research Grant from the Japanese Ministry of Education (C, No. 56570383).
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University School of Medicine
発行日 1981-09-10
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6795150