Carbonic Anhydrase I and II Levels in Erythrocytes of Chronic Renal Disease Patients
Hiroshima Journal of Medical Sciences 31 巻 1 号
1-6 頁
1982-03-10 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Carbonic Anhydrase I and II Levels in Erythrocytes of Chronic Renal Disease Patients
|
| タイトル ( jpn ) |
慢性腎疾患患者における赤血球炭酸脱水酵素レベル
|
| 作成者 |
Yamakido Michio
Yorioka Noriaki
Goriki Kazuaki
Wada Koji
Hata Jyotaro
Nishimoto Yukio
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 31 |
| 号 | 1 |
| 開始ページ | 1 |
| 終了ページ | 6 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Carbonic anhydrase isozymes, carbonic anhydrase I and II, also known as carbonate dehydratase, were isolated and purified from human erythrocytes. Rabbits were then immunized and the respective types of antisera were prepared. Using the antisera obtained, the carbonic anhydrase I and II levels in erythrocytes of healthy persons and patients with chronic glomerulonephritis, primary nephrotic syndrome, lupus nephritis and those undergoing chronic hemodialysis were determined by the single radial immunodiffusion method.
Results showed that primary nephrotic syndrome, lupus nephritis and chronic hemodialysis patients had significantly higher carbonic anhydrase I levels than healthy persons, but an increase in carbonic anhydrase I level could not be demonstrated in patients with chronic glomerulonephritis. The carbonic anhydrase II level in chronic glomerulonephritis, primary nephrotic syndrome, lupus nephritis and chronic hemodialysis patients was significantly higher than that of healthy persons. Further, in the patients with chronic glomerulonephritis, a significant positive correlation was observed between carbonic anhydrase I and BUN, serum creatinine and total cholesterol levels, while there was a negative correlation between the PSP 15-minute value. Also a significant positive correlation was found between carbonic anhydrase II and total cholesterol levels. It is concluded that the determination of carbonic anhydrase I and II levels in human erythrocytes are important for the follow-up and evaluation of prognosis in chronic renal disease patients. |
| 著者キーワード |
Carbonic anhydrase
Glomerulonephritis
Nephrotic syndrome
Chronic hemodialysis
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1982-03-10 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6807940
|
