Carbonic Anhydrase I and II Levels in Erythrocytes of Chronic Renal Disease Patients
Hiroshima Journal of Medical Sciences Volume 31 Issue 1
Page 1-6
published_at 1982-03-10
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| File | |
| Title ( eng ) |
Carbonic Anhydrase I and II Levels in Erythrocytes of Chronic Renal Disease Patients
|
| Title ( jpn ) |
慢性腎疾患患者における赤血球炭酸脱水酵素レベル
|
| Creator |
Yamakido Michio
Yorioka Noriaki
Goriki Kazuaki
Wada Koji
Hata Jyotaro
Nishimoto Yukio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 31 |
| Issue | 1 |
| Start Page | 1 |
| End Page | 6 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Carbonic anhydrase isozymes, carbonic anhydrase I and II, also known as carbonate dehydratase, were isolated and purified from human erythrocytes. Rabbits were then immunized and the respective types of antisera were prepared. Using the antisera obtained, the carbonic anhydrase I and II levels in erythrocytes of healthy persons and patients with chronic glomerulonephritis, primary nephrotic syndrome, lupus nephritis and those undergoing chronic hemodialysis were determined by the single radial immunodiffusion method.
Results showed that primary nephrotic syndrome, lupus nephritis and chronic hemodialysis patients had significantly higher carbonic anhydrase I levels than healthy persons, but an increase in carbonic anhydrase I level could not be demonstrated in patients with chronic glomerulonephritis. The carbonic anhydrase II level in chronic glomerulonephritis, primary nephrotic syndrome, lupus nephritis and chronic hemodialysis patients was significantly higher than that of healthy persons. Further, in the patients with chronic glomerulonephritis, a significant positive correlation was observed between carbonic anhydrase I and BUN, serum creatinine and total cholesterol levels, while there was a negative correlation between the PSP 15-minute value. Also a significant positive correlation was found between carbonic anhydrase II and total cholesterol levels. It is concluded that the determination of carbonic anhydrase I and II levels in human erythrocytes are important for the follow-up and evaluation of prognosis in chronic renal disease patients. |
| Keywords |
Carbonic anhydrase
Glomerulonephritis
Nephrotic syndrome
Chronic hemodialysis
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1982-03-10 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6807940
|
