Effect of Streptococcal Preparation, OK-432, on Experimental Infection due to Mycobacterium lepraemurium in Mice of C3H/Jms Strain
Hiroshima Journal of Medical Sciences 32 巻 2 号
231-234 頁
1983-06 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Effect of Streptococcal Preparation, OK-432, on Experimental Infection due to Mycobacterium lepraemurium in Mice of C3H/Jms Strain
|
| タイトル ( jpn ) |
CH3/Jms 系マウスにおける実験的鼠ライ菌感染におよぼす溶連菌製剤 OK-432 の効果
|
| 作成者 |
Saito Hajime
Tomioka Haruaki
Sato Katsumasa
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 32 |
| 号 | 2 |
| 開始ページ | 231 |
| 終了ページ | 234 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Streptococcal preparation, OK-432, was examined for its therapeutic effect on experimental infection due to Mycobacterium lepraemurium (Mlm) in mice, When C3H/Jms mice (Mlm-sensitive strain) were infected with 10^8 Mlm to the left hind footpad, weekly injections of OK-432 via the peritoneal route (0.1 mg dry weight per injection), it considerably enhanced elimination of organisms from the infection site during the first 6 weeks, and thereafter suppressed the growth of organisms during 6 to 23 weeks after infection. In contrast, weekly injections of OK-432 to the infection site (left hind footpad) resulted in the enhanced growth of Mlm in the infection site, indicating that multiple injections of OK-432 to the infection site might generate suppressor cells and/or antagonizing factors against the host defense mechanisms to Mlm.
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| 著者キーワード |
OK-432
Mycobacterium lepraemurium
Infection
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1983-06 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6352569
|
