Effect of Streptococcal Preparation, OK-432, on Experimental Infection due to Mycobacterium lepraemurium in Mice of C3H/Jms Strain

CH3/Jms 系マウスにおける実験的鼠ライ菌感染におよぼす溶連菌製剤 OK-432 の効果

Saito Hajime

Tomioka Haruaki

Sato Katsumasa

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Streptococcal preparation, OK-432, was examined for its therapeutic effect on experimental infection due to Mycobacterium lepraemurium (Mlm) in mice, When C3H/Jms mice (Mlm-sensitive strain) were infected with 10^8 Mlm to the left hind footpad, weekly injections of OK-432 via the peritoneal route (0.1 mg dry weight per injection), it considerably enhanced elimination of organisms from the infection site during the first 6 weeks, and thereafter suppressed the growth of organisms during 6 to 23 weeks after infection. In contrast, weekly injections of OK-432 to the infection site (left hind footpad) resulted in the enhanced growth of Mlm in the infection site, indicating that multiple injections of OK-432 to the infection site might generate suppressor cells and/or antagonizing factors against the host defense mechanisms to Mlm.

OK-432

Mycobacterium lepraemurium

Infection

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6352569