Functional Analysis of Polymorphonuclear Leukocytes in Siblings of Glucose-6-Phosphate Dehydrogenase Deficiency
Hiroshima Journal of Medical Sciences 32 巻 2 号
173-178 頁
1983-06 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Functional Analysis of Polymorphonuclear Leukocytes in Siblings of Glucose-6-Phosphate Dehydrogenase Deficiency
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| タイトル ( jpn ) |
ブドウ糖6リン酸脱水素酵素欠損症同胞例の多核白血球機能
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| 作成者 |
Matsuura Ryoji
Kishi Takamasa
Okahata Hiroyasu
Tanabe Akio
Sakura Nobuo
Sawano Kunihiko
Usui Tomofusa
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 32 |
| 号 | 2 |
| 開始ページ | 173 |
| 終了ページ | 178 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Several functions of polymorphonuclear leukocytes (PMNL) were examined in two siblings with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In spite of marked depression of G6PD activity of PMNL, the patients had no susceptibility to bacterial infections. Qualitative nitroblue tetrazolium (NET) reduction was normal in both cases. Quantitative NBT reduction was normal in one case and subnormal in the other. Bactericidal activity also was normal. However, superoxide anion (O2-) release, oxygen (O2) consumption and chemiluminescence (CL) response were significantly decreased in both cases. This dysfunction was more marked when glucose was added extracellularly. It is concluded that these tests are more suitable than the NBT test for the screening of PMNL G6PD deficiency. It is also considered that there is a large reserve supply of active oxygens necessary for normal bactericidal activity of PMNL.
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| 著者キーワード |
Glucose-6-phosphate dehydrogenase
Polymorphonuclear leukocytes
Chronic granulomatous disease
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| 内容記述 |
This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Scientific and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1983-06 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6618900
|
