Functional Analysis of Polymorphonuclear Leukocytes in Siblings of Glucose-6-Phosphate Dehydrogenase Deficiency
Hiroshima Journal of Medical Sciences Volume 32 Issue 2
Page 173-178
published_at 1983-06
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| File | |
| Title ( eng ) |
Functional Analysis of Polymorphonuclear Leukocytes in Siblings of Glucose-6-Phosphate Dehydrogenase Deficiency
|
| Title ( jpn ) |
ブドウ糖6リン酸脱水素酵素欠損症同胞例の多核白血球機能
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| Creator |
Matsuura Ryoji
Kishi Takamasa
Okahata Hiroyasu
Tanabe Akio
Sakura Nobuo
Sawano Kunihiko
Usui Tomofusa
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 32 |
| Issue | 2 |
| Start Page | 173 |
| End Page | 178 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
Several functions of polymorphonuclear leukocytes (PMNL) were examined in two siblings with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In spite of marked depression of G6PD activity of PMNL, the patients had no susceptibility to bacterial infections. Qualitative nitroblue tetrazolium (NET) reduction was normal in both cases. Quantitative NBT reduction was normal in one case and subnormal in the other. Bactericidal activity also was normal. However, superoxide anion (O2-) release, oxygen (O2) consumption and chemiluminescence (CL) response were significantly decreased in both cases. This dysfunction was more marked when glucose was added extracellularly. It is concluded that these tests are more suitable than the NBT test for the screening of PMNL G6PD deficiency. It is also considered that there is a large reserve supply of active oxygens necessary for normal bactericidal activity of PMNL.
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| Keywords |
Glucose-6-phosphate dehydrogenase
Polymorphonuclear leukocytes
Chronic granulomatous disease
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| Descriptions |
This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Scientific and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation.
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| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1983-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6618900
|
