Cytogenetical Analysis of the Human Gastric Carcinoma Cell Line TMK-1
Hiroshima Journal of Medical Sciences 38 巻 3 号
121-124 頁
1989-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Cytogenetical Analysis of the Human Gastric Carcinoma Cell Line TMK-1
|
| 作成者 |
Ito Hisao
Oda Noriko
Kameda Takashi
Nakayama Hirofumi
Tahara Eiichi
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 38 |
| 号 | 3 |
| 開始ページ | 121 |
| 終了ページ | 124 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
We examined a human gastric carcinoma cell line TMK-1 cytogenetically by G-banding technique. TMK-1 cells were characterized not only by numerical aberrations but also by structural rearrangements affecting various chromosomes. The modal chromosome number was found to be in the hypotriploid range with most ranging between 64 and 66. Flow cytometry revealed near triploid DNA histogram which was correlated well with chromosome counts. Gain of chromosome 7, 9, 11, and X was found in all of the 25 cells examined and trisomy of chromosome 3, 5, 10, 19, 21 and 22 was also frequently detected. Loss of Y chromosome was shown in all of the cells and monosomy of chromosome 6 and 13 was frequently detected. The most conspicuous rearrangements involved chromosome 6, 12, and 16 which showed complex nonreciprocal translocation. Twenty-two cells (88%) had isochromosome of 12q. A brief review is made of reported karyotype of human gastric cancers.
|
| 著者キーワード |
Hwnan stomach cancer
TMK-1 cell
Cytogenetics
Flow cytometly
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| 内容記述 |
This study was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare, Tokyo and Tsuchiya Medical Foundation, Hiroshima, Japan.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1989-09 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584055
|
