Cytogenetic Abnormalities of Hematopoietic Tissue in Retired Workers of the Ohkunojima Poison Gas Factory
Hiroshima Journal of Medical Sciences 42 巻 4 号
159-165 頁
1993-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Cytogenetic Abnormalities of Hematopoietic Tissue in Retired Workers of the Ohkunojima Poison Gas Factory
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| 作成者 |
Shakil Fouzia A.
Kuramoto Atsushi
Yamakido Michio
Nishimoto Yukio
Kamada Nanao
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 42 |
| 号 | 4 |
| 開始ページ | 159 |
| 終了ページ | 165 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
A high incidence of cancer of the respiratory tract has been reported among former workers in a poison gas manufacturing plant which operated on Ohkunojima from 1927 to 1945. This report provides evidence of a high incidence of chromosome abnormality and sister chromatid exchange (SCE) rate among the former workers, as well as cytogenetic changes in two patients among the former workers with chronic myelocytic leukemia (CML). A chromosome study of seven former workers with chronic bronchitis revealed a stable type of aberration, the average abnormality being 10.9 ± 4.4 percent, which is equivalent to those of atomic bomb survivors exposed at 1.2 km from the hypocenter. The SCE rate observed in 16 former workers ranged from 4.9 ± 2.1 to 17.8 ± 3.9, which was significantly higher than in the control group (p<0.03). One of the CML patients showed an extremely high percentage of missing Y chromosomes along with t(9;22) translocation which is a specific chromosome aberration for the disease. Furthermore, the patient had almost a 3 times higher SCE rate compared to the control group and a high incidence of chromosome abnormality (12.1 %) of the peripheral lymphocytes. These results suggest that the development of leukemia in this patient was strongly related to poison gas exposure.
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| 著者キーワード |
Mustard gas
Chromosome abnormality
Sister chromatid exchange
Chronic myelocytic leukemia
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| 内容記述 |
This work was supported in part by grants-in-aid from the Ministry of Education, Science and Culture and from the Japan Public Health Association's A-Bomb Survivors Joint Research Team supported by FY 1992 Health and Welfare Ministry A-Bomb Disease Investigation and Research Entrustment Fund (Shigematsu Collaborative Study Group).
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
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| 発行日 | 1993-12 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
