Cytogenetic Abnormalities of Hematopoietic Tissue in Retired Workers of the Ohkunojima Poison Gas Factory
Hiroshima Journal of Medical Sciences Volume 42 Issue 4
Page 159-165
published_at 1993-12
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| File | |
| Title ( eng ) |
Cytogenetic Abnormalities of Hematopoietic Tissue in Retired Workers of the Ohkunojima Poison Gas Factory
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| Creator |
Shakil Fouzia A.
Kuramoto Atsushi
Yamakido Michio
Nishimoto Yukio
Kamada Nanao
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| Source Title |
Hiroshima Journal of Medical Sciences
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| Volume | 42 |
| Issue | 4 |
| Start Page | 159 |
| End Page | 165 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
A high incidence of cancer of the respiratory tract has been reported among former workers in a poison gas manufacturing plant which operated on Ohkunojima from 1927 to 1945. This report provides evidence of a high incidence of chromosome abnormality and sister chromatid exchange (SCE) rate among the former workers, as well as cytogenetic changes in two patients among the former workers with chronic myelocytic leukemia (CML). A chromosome study of seven former workers with chronic bronchitis revealed a stable type of aberration, the average abnormality being 10.9 ± 4.4 percent, which is equivalent to those of atomic bomb survivors exposed at 1.2 km from the hypocenter. The SCE rate observed in 16 former workers ranged from 4.9 ± 2.1 to 17.8 ± 3.9, which was significantly higher than in the control group (p<0.03). One of the CML patients showed an extremely high percentage of missing Y chromosomes along with t(9;22) translocation which is a specific chromosome aberration for the disease. Furthermore, the patient had almost a 3 times higher SCE rate compared to the control group and a high incidence of chromosome abnormality (12.1 %) of the peripheral lymphocytes. These results suggest that the development of leukemia in this patient was strongly related to poison gas exposure.
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| Keywords |
Mustard gas
Chromosome abnormality
Sister chromatid exchange
Chronic myelocytic leukemia
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| Descriptions |
This work was supported in part by grants-in-aid from the Ministry of Education, Science and Culture and from the Japan Public Health Association's A-Bomb Survivors Joint Research Team supported by FY 1992 Health and Welfare Ministry A-Bomb Disease Investigation and Research Entrustment Fund (Shigematsu Collaborative Study Group).
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
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| Date of Issued | 1993-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
