Effect of N-Feruloyl Tyramine (an Analogue of Tyramine) on Inwardly Rectifying Potassium Channel in Frog Ventricular Myocytes

Hiroshima Journal of Medical Sciences 45 巻 1 号 31-35 頁 1996-03 発行

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タイトル ( eng )	Effect of N-Feruloyl Tyramine (an Analogue of Tyramine) on Inwardly Rectifying Potassium Channel in Frog Ventricular Myocytes
作成者	Munemori Makoto Yamaoka Kaoru Yusuf Irawan Sumii Kotaro Otsuka Hideaki Yamasaki Kazuo
収録物名	Hiroshima Journal of Medical Sciences
巻	45
号	1
開始ページ	31
終了ページ	35
収録物識別子	[PISSN] 0018-2052 [EISSN] 2433-7668 [NCID] AA00664312
抄録	Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 μM, while tyramine (100 μM) was ineffective in producing an inhibitory effect on iK1. NFT reduced the mean open time of iK1 to 1.3 ms from 3.1 ms in control without affecting the amplitude of single-channel conductance. It is indicated that boi containing NFT produces a prolongation of the plateau phase caused by the suppression of inwardly rectifying K channel. Thus, this prolongation may induce an increase in the inflow of Ca ions, which in turn leads to a positive inotropic effect.
著者キーワード	NFT iK1 Suppression
内容記述	This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas from the Japanese Ministry of Education, Science and Culture (Grant number 02257101, 03253101 and 04248101), and the Uehara Memorial Foundation.
NDC分類	医学 [ 490 ]
言語	英語
資源タイプ	紀要論文
出版者	Hiroshima University Medical Press
発行日	1996-03
出版タイプ	Version of Record（出版社版。早期公開を含む）
アクセス権	オープンアクセス
収録物識別子	[ISSN] 0018-2052 [NCID] AA00664312