Effect of N-Feruloyl Tyramine (an Analogue of Tyramine) on Inwardly Rectifying Potassium Channel in Frog Ventricular Myocytes
Hiroshima Journal of Medical Sciences Volume 45 Issue 1
Page 31-35
published_at 1996-03
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| File | |
| Title ( eng ) |
Effect of N-Feruloyl Tyramine (an Analogue of Tyramine) on Inwardly Rectifying Potassium Channel in Frog Ventricular Myocytes
|
| Creator |
Munemori Makoto
Yamaoka Kaoru
Yusuf Irawan
Sumii Kotaro
Otsuka Hideaki
Yamasaki Kazuo
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| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 45 |
| Issue | 1 |
| Start Page | 31 |
| End Page | 35 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 μM, while tyramine (100 μM) was ineffective in producing an inhibitory effect on iK1. NFT reduced the mean open time of iK1 to 1.3 ms from 3.1 ms in control without affecting the amplitude of single-channel conductance. It is indicated that boi containing NFT produces a prolongation of the plateau phase caused by the suppression of inwardly rectifying K channel. Thus, this prolongation may induce an increase in the inflow of Ca ions, which in turn leads to a positive inotropic effect.
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| Keywords |
NFT
iK1
Suppression
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| Descriptions |
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas from the Japanese Ministry of Education, Science and Culture (Grant number 02257101, 03253101 and 04248101), and the Uehara Memorial Foundation.
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
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| Date of Issued | 1996-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
