Ammonia Determination as an Early Indicator in Experimental Superior Mesenteric Artery Occlusion
Hiroshima Journal of Medical Sciences Volume 46 Issue 4
Page 159-167
published_at 1997-12
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| File | |
| Title ( eng ) |
Ammonia Determination as an Early Indicator in Experimental Superior Mesenteric Artery Occlusion
|
| Creator |
Watari Masanobu
Murakami Hironobu
Orihashi Kazumasa
Matsuura Yuichiro
Kajihara Hiroki
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 46 |
| Issue | 4 |
| Start Page | 159 |
| End Page | 167 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Superior mesenteric artery occlusion (SMAO) is often fatal. An indicator which enables the early diagnosis of SMAO is needed. As we think putrefaction products must appear and increase in the blood and ascites in SMAO, changes in the concentrations of ammonia, one of the putrefaction products, were measured in this study.
Thirteen adult mongrel dogs were used for the in vitro experiment. The jejunum, ileum, and ascending colon were resected and incubated in saline. Changes in ammonia concentrations in the saline were examined at various incubation times. In the in vivo experiment, 11 mongrel dogs comprised the SMAO group and another 10 mongrel dogs comprised the control group. Changes in ammonia concentrations in the blood and ascites were examined in both groups. In the in vitro experiment, ammonia concentrations in the saline bath increased in all samples. It was highest in the sample from around the ascending colon, and lowest from around the jejunum. However, at the end of experiment, this difference became insignificant. In the in vivo experiment, ammonia concentrations in samples of the blood increased early and significantly in the SMAO group, compared with the control group. Ammonia concentrations in samples of the ascites also increased significantly. The in vitro experiment showed that ammonia leaked from the ischemic intestines, and secondarily, a large amount of ammonia was produced from intestinal putrefaction. The in vivo experiment revealed that the ammonia level in the blood could be used as a good early indicator of acute mesenteric ischemia. |
| Keywords |
Ammonia
Putrefaction
Mesenteric ischemia
Superior mesenteric artery occlusion
|
| Descriptions |
This work was presented at the 96th Annual Meeting of the Japan Society for Surgery, Makuhari, 1996.
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1997-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
